Epidermal Inclusion Cyst

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Background

Epidermoid cysts represent the most common cutaneous cysts. While they may occur anywhere on the body, they occur most frequently on the face, scalp, neck, and trunk.[1]

Historically, epidermoid cysts have been referred to by various terms, including follicular infundibular cysts, epidermal cysts, and epidermal inclusion cysts. The term epidermal inclusion cyst refers specifically to an epidermoid cyst that is the result of the implantation of epidermal elements in the dermis. Because most lesions originate from the follicular infundibulum, the more general term epidermoid cyst is favored. The term sebaceous cyst should be avoided because it implies that the cyst is of sebaceous origin. Finally, the term milia refers to very small, superficial epidermoid cysts.

Epidermoid cysts are benign lesions; however, very rare cases of various associated malignancies have been reported.[2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13]

Pathophysiology

Epidermoid cysts result from the proliferation of epidermal cells within a circumscribed space of the dermis. Analysis of their lipid pattern demonstrates similarities to the epidermis. In addition, epidermoid cysts express cytokeratins 1 and 10, which are constituents of the suprabasilar layers of the epidermis. The source of this epidermis is nearly always the infundibulum of the hair follicle, as evidenced by the observation that the lining of the 2 structures is identical.[13]

Inflammation is mediated in part by the horny material contained in epidermoid cysts. Extracts of this material have been shown to be chemotactic for polymorphonucleocytes.

Studies have suggested that human papillomavirus (HPV) and exposure to ultraviolet light (UV) may play a role in the formation of some epidermoid cysts, particularly verrucous cysts with coarse hypergranulosis.[14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25]

The manner in which carcinomas may arise within epidermoid cysts is unclear. In a series of epidermoid cysts with carcinoma, immunohistochemical results for HPV were negative, suggesting that HPV is not likely to play a role in the development in squamous cell carcinoma (SCC) in epidermoid cysts. Chronic irritation or repetitive trauma to the epithelial lining of the cyst has been suggested to play a role in malignant transformation; however, this relationship has not been established.[44]

Epidemiology

Race

No racial predilection has been identified. Pigmentation of epidermoid cysts is common in individuals with dark skin. In a study of Indian patients with epidermoid cysts, 63% of the cysts contained melanin pigment.[26]

Sex

Epidermoid cysts are approximately twice as common in men as in women.

Age

Epidermoid cysts may occur at any age; however, they most commonly arise in the third and fourth decades of life. Small epidermoid cysts known as milia are common in the neonatal period.

Prognosis

Epidermoid cysts are usually asymptomatic; however, they may become inflamed or secondarily infected, resulting in swelling and tenderness. Rarely, malignancies, including basal cell carcinoma, Bowen disease, SCC (most common of these rarities), mycosis fungoides, and melanoma in situ, have developed in epidermoid cysts.[13]

History

Epidermoid cysts are usually asymptomatic. Discharge of a foul-smelling “cheeselike” material may be described. Less frequently, the cysts can become inflamed or infected, resulting in pain and tenderness. In the uncommon event of malignancy, rapid growth, friability, and bleeding may be reported.

Physical Examination

Epidermoid cysts appear as flesh–colored-to-yellowish, firm, round nodules of variable size. A central pore or punctum may be present. Note the image below.



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Unusually large epidermoid cyst with a prominent punctum on the back of a patient. (Ruler is in centimeters.)

Reportedly, epidermoid cysts are most common (in descending order of frequency) on the face, trunk, neck, extremities, and scalp. Rare cases of epidermoid cysts occurring in bone, breast, and various intracranial locations have been reported.[33] Epidermoid cysts in the breast and genital area are not uncommon in the general population. The ocular and oral mucosae can also be affected and, cysts have been reported on the palpebral conjunctivae, lips, buccal mucosa, tongue, and uvula.

Epidermoid cysts can manifest in various ways on the extremities. Epidermoid cysts on the distal portions of the digits may extend into the terminal phalanx. These lesions may produce changes in the nails such as pincer nails, erythema, edema, tenderness, and pain.[34]

Causes

Epidermoid cysts likely form by several mechanisms. They may result from the sequestration of epidermal rests during embryonic life, occlusion of the pilosebaceous unit, or traumatic or surgical implantation of epithelial elements. HPV infection, ultraviolet exposure, and eccrine duct occlusion may be additional factors in the development of palmoplantar epidermoid cysts.[27] HPV has also been identified in nonpalmoplantar epidermoid cysts.

Congenital epidermoid cysts of the anterior fontanelle or those that are orogenital in location presumably result from sequestration or trapping of epidermal rests along embryonic fusion planes during development. Lip and lingual lesions may be related to aberrant fusion of the branchial arches, while genital lesions may result from improper closure of the genital folds.

Any benign or malignant process affecting or growing near the pilosebaceous unit may lead to occlusion or impingement of the follicular ostia with subsequent formation of a cyst. Cysts with an acneiform distribution are likely the result of follicular occlusion. In elderly persons, accumulated sun damage can injure the pilosebaceous unit, causing abnormalities such as comedonal plugging and hypercornification, both of which can eventuate in cyst formation.[28] This condition is referred to as Favre-Racouchot syndrome.

True epidermal inclusion cysts result from the implantation of epithelial elements in the dermis. Certain injuries, especially of the crushing type, have been associated with subungual or terminal phalanx epidermoid cysts. A crush injury sustained from slamming a car door on a digit is frequently reported. Any surgical procedure can theoretically result in epidermoid cysts. Reports describe the formation of multiple epidermoid cysts after rhinoplasty, breast augmentation, and liposuction.[29] The use of dermal grafts, myocutaneous grafts, and needle biopsies has also been associated with the formation of epidermoid cysts.

Certain hereditary syndromes are associated with epidermoid cysts. Such syndromes include Gardner syndrome,[30] basal cell nevus syndrome,[3, 10, 25] and pachyonychia congenita.[31, 32] In addition, idiopathic scrotal calcinosis may actually represent an end stage of dystrophic calcification of epidermoid cysts. Note the image below.



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Multiple epidermoid cysts on the forehead of a patient with Gardner syndrome.

Laboratory Studies

Laboratory studies are typically unnecessary; however, with recurrent infection or lack of response to antibiotics, a culture and sensitivity may be obtained.

Imaging Studies

If an epidermoid cyst is suspected in an unusual location, such as breast, bone, or intracranial locations, imaging with ultrasonography, radiography, CT scanning, or MRI is appropriate.

Other Tests

Fine-needle aspiration has been used to help diagnose epidermoid cysts in unusual locations, such as the breast. Smears of aspirated material stained with Wright-Giemsa stain demonstrate nucleated keratinocytes and wavy keratin material.[1]

Histologic Findings

Epidermoid cysts are lined with stratified squamous epithelium that contains a granular layer. Laminated keratin contents are noted inside the cyst. An inflammatory response may be present in cysts that have ruptured. Older cysts may exhibit calcification. Pilomatrical differentiation may be noted, especially in patients with Gardner syndrome.[35]

Note the images below.



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Cyst containing keratinous material (hematoxylin and eosin, original magnification X1.6).



View Image

Higher-magnification view of the cyst wall of the cyst in Media File 3 demonstrates a true epidermis with a granular layer and adjacent laminated kera....

Medical Care

Asymptomatic epidermoid cysts do not need to be treated. Intralesional injection with triamcinolone may hasten the resolution of inflammation. Oral antibiotics may occasionally be indicated.

Surgical Care

Epidermoid cysts may be removed via simple excision or incision with removal of the cyst and cyst wall though the surgical defect.[36] If the entire cyst wall is not removed, the lesion may recur. Excision with punch biopsy technique may be used if the size of the lesion permits.[37, 38] Minimal-incision surgery, with reduced scarring, has been reported.[39, 40]  An intraoral approach has been used to minimize facial scarring.[45]

Incision and drainage may be performed if a cyst is inflamed. Injection of triamcinolone into the tissue surrounding the inflamed cyst results in faster improvement in symptoms. This may facilitate the clearing of infection; however, it does not eradicate the cyst.

Consultations

Lesions located in atypical locations warrant appropriate consultation.

Complications

Complications are rare, but they can include infection, scarring from removal, and recurrence. Malignancies in epidermoid cysts are very rare.

Prevention

When the cutaneous portion of a myocutaneous flap is to be buried, a dermatome should be used to remove the epidermis.

Guideline Summary

The Infectious Diseases Society of America recently updated their guidelines for the diagnosis and management of skin and soft tissue infections. For the full guidelines, see Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America.[41, 42]

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

Triamcinolone (Amcort, Aristocort)

Clinical Context:  Triamcinolone decreases inflammation by suppressing the migration of PMN leukocytes and reversing capillary permeability. Intralesional injections may be used for localized skin disorders.

Class Summary

These agents have anti-inflammatory properties and cause varied metabolic effects.

What are epidermal inclusion cysts (EIC)?What is the pathophysiology of epidermal inclusion cysts (EIC)?What are risk factors for the formation of epidermal inclusion cysts (EIC)?What is the pathogenesis of carcinoma in epidermal inclusion cysts (EIC)?What are the racial predilections of epidermal inclusion cysts (EIC)?How does the prevalence of epidermal inclusion cysts (EIC) vary between men and women?How does the incidence of epidermal inclusion cysts (EIC) vary by age?What is the prognosis of epidermal inclusion cysts (EIC)?What are the signs and symptoms of epidermal inclusion cysts (EIC)?What is the appearance of epidermal inclusion cysts (EIC) on physical exam?Where do epidermal inclusion cysts (EIC) most commonly appear?How do epidermal inclusion cysts (EIC) manifest on the extremities?How do epidermal inclusion cysts (EIC) form?What is the role of injury in the etiology of epidermal inclusion cysts (EIC)?Which hereditary syndromes are associated with epidermal inclusion cysts (EIC)?What are the differential diagnoses for Epidermal Inclusion Cyst?What is the role of lab studies in the evaluation of epidermal inclusion cysts (EIC)?What is the role of imaging studies in the evaluation of epidermal inclusion cysts (EIC)?What is the role of fine-needle aspiration (FNA) in the diagnosis of epidermal inclusion cysts (EIC)?Which histologic findings are characteristic of epidermal inclusion cysts (EIC)?Which medications are used in the treatment of epidermal inclusion cysts (EIC)?What is the role of surgery in the treatment of epidermal inclusion cysts (EIC)?How are inflamed epidermal inclusion cysts (EIC) managed?When is a specialist consultation indicated for the treatment of epidermal inclusion cysts (EIC)?What are possible complications of epidermal inclusion cysts (EIC)?Which procedure to used to prevent epidermal inclusion cysts (EIC) from worsening?What guidelines are available for the diagnosis and treatment of epidermal inclusion cysts (EIC)?What is the goal of drug treatment for epidermal inclusion cysts (EIC)?Which medications in the drug class Corticosteroids are used in the treatment of Epidermal Inclusion Cyst?

Author

Linda J Fromm, MD, MA, FAAD, Private Practice, Fromm Dermatology at Health Concepts, Rapid City, South Dakota

Disclosure: Nothing to disclose.

Coauthor(s)

Nathalie C Zeitouni, MDCM, FRCPC, Chair of Dermatology, Associate Professor of Dermatology, Roswell Park Cancer Institute

Disclosure: Nothing to disclose.

Specialty Editors

David F Butler, MD, Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

Disclosure: Nothing to disclose.

Christen M Mowad, MD, Professor, Department of Dermatology, Geisinger Medical Center

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Disclosure: Nothing to disclose.

Additional Contributors

Julie C Harper, MD, Assistant Program Director, Assistant Professor, Department of Dermatology, University of Alabama at Birmingham

Disclosure: Received honoraria from Stiefel for speaking and teaching; Received honoraria from Allergan for speaking and teaching; Received honoraria from Intendis for speaking and teaching; Received honoraria from Coria for speaking and teaching; Received honoraria from Sanofi-Aventis for speaking and teaching.

Acknowledgements

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous authors, Kenneth A. Becker, MD, and Isabelle Thomas, MD, to the development and writing of this article.

References

  1. Handa U, Kumar S, Mohan H. Aspiration cytology of epidermoid cyst of terminal phalanx. Diagn Cytopathol. 2002 Apr. 26(4):266-7. [View Abstract]
  2. Aloi F, Tomasini C, Pippione M. Mycosis fungoides and eruptive epidermoid cysts: a unique response of follicular and eccrine structures. Dermatology. 1993. 187(4):273-7. [View Abstract]
  3. Barr RJ, Headley JL, Jensen JL, Howell JB. Cutaneous keratocysts of nevoid basal cell carcinoma syndrome. J Am Acad Dermatol. 1986 Apr. 14(4):572-6. [View Abstract]
  4. Bauer B. Carcinoma arising in a sebaceous cyst. IMJ Ill Med J. 1979 Sep. 156(3):174-6. [View Abstract]
  5. Cameron DS, Hilsinger RL Jr. Squamous cell carcinoma in an epidermal inclusion cyst: case report. Otolaryngol Head Neck Surg. 2003 Jul. 129(1):141-3. [View Abstract]
  6. Delacretaz J. Keratotic basal-cell carcinoma arising from an epidermoid cyst. J Dermatol Surg Oncol. 1977 May-Jun. 3(3):310-1. [View Abstract]
  7. King LA, Barr RJ, Gottschalk HR. Mycosis fungoides with underlying epidermoid cysts. Arch Dermatol. 1979 May. 115(5):622. [View Abstract]
  8. Levine DJ, Robertson DB, Varma VA. Familial subconjunctival epithelial cysts associated with the nevoid basal cell carcinoma syndrome. Arch Dermatol. 1987 Jan. 123(1):23-4. [View Abstract]
  9. Lopez-Rios F, Rodriguez-Peralto JL, Castano E, Benito A. Squamous cell carcinoma arising in a cutaneous epidermal cyst: case report and literature review. Am J Dermatopathol. 1999 Apr. 21(2):174-7. [View Abstract]
  10. Ogata K, Ikeda M, Miyoshi K, et al. Naevoid basal cell carcinoma syndrome with a palmar epidermoid cyst, milia and maxillary cysts. Br J Dermatol. 2001 Sep. 145(3):508-9. [View Abstract]
  11. Perse RM, Klappenbach RS, Ragsdale BD. Trabecular (Merkel cell) carcinoma arising in the wall of an epidermal cyst. Am J Dermatopathol. 1987 Oct. 9(5):423-7. [View Abstract]
  12. Tanaka M, Terui T, Sasai S, Tagami H. Basal cell carcinoma showing connections with epidermal cysts. J Eur Acad Dermatol Venereol. 2003 Sep. 17(5):581-2. [View Abstract]
  13. Swygert KE, Parrish CA, Cashman RE, Lin R, Cockerell CJ. Melanoma in situ involving an epidermal inclusion (infundibular) cyst. Am J Dermatopathol. 2007 Dec. 29(6):564-5. [View Abstract]
  14. Egawa K, Kitasato H, Honda Y, Kawai S, Mizushima Y, Ono T. Human papillomavirus 57 identified in a plantar epidermoid cyst. Br J Dermatol. 1998 Mar. 138(3):510-4. [View Abstract]
  15. Egawa K, Honda Y, Inaba Y, Ono T, De Villiers EM. Detection of human papillomaviruses and eccrine ducts in palmoplantar epidermoid cysts. Br J Dermatol. 1995 Apr. 132(4):533-42. [View Abstract]
  16. Egawa K, Honda Y, Inaba Y, Kojo Y, Ono T, de Villiers EM. Multiple plantar epidermoid cysts harboring carcinoembryonic antigen and human papillomavirus DNA sequences. J Am Acad Dermatol. 1994 Mar. 30(3):494-6. [View Abstract]
  17. Egawa K, Inaba Y, Ono T, Arao T. Cystic papilloma' in humans? Demonstration of human papillomavirus in plantar epidermoid cysts. Arch Dermatol. 1990 Dec. 126(12):1599-603. [View Abstract]
  18. Egawa K, Egawa N, Honda Y. Human papillomavirus-associated plantar epidermoid cyst related to epidermoid metaplasia of the eccrine duct epithelium: a combined histological, immunohistochemical, DNA-DNA in situ hybridization and three-dimensional reconstruction analysis. Br J Dermatol. 2005 May. 152(5):961-7. [View Abstract]
  19. Kato N, Ueno H. Two cases of plantar epidermal cyst associated with human papillomavirus. Clin Exp Dermatol. 1992 Jul. 17(4):252-6. [View Abstract]
  20. Kawase M, Honda M, Niimura M. Detection of human papillomavirus type 60 in plantar cysts and verruca plantaris by the in situ hybridization method using digoxigenin labeled probes. J Dermatol. 1994 Oct. 21(10):709-15. [View Abstract]
  21. Kitasato H, Egawa K, Honda Y, Ono T, Mizushima Y, Kawai S. A putative human papillomavirus type 57 new subtype isolated from plantar epidermoid cysts without intracytoplasmic inclusion bodies. J Gen Virol. 1998 Aug. 79 (Pt 8):1977-81. [View Abstract]
  22. Lee S, Lee W, Chung S, et al. Detection of human papillomavirus 60 in epidermal cysts of nonpalmoplantar location. Am J Dermatopathol. 2003 Jun. 25(3):243-7. [View Abstract]
  23. Morgan MB, Stevens GL, Somach S, Tannenbaum M. Carcinoma arising in epidermoid cyst: a case series and aetiological investigation of human papillomavirus. Br J Dermatol. 2001 Sep. 145(3):505-6. [View Abstract]
  24. Park HS, Kim WS, Lee JH, et al. Association of human papillomavirus infection with palmoplantar epidermal cysts in Korean patients. Acta Derm Venereol. 2005. 85(5):404-8. [View Abstract]
  25. Rios-Buceta LM, Fraga-Fernandez J, Fernandez-Herrera J. Human papillomavirus in an epidermoid cyst of the sole in a non-Japanese patient. J Am Acad Dermatol. 1992 Aug. 27(2 Pt 2):364-6. [View Abstract]
  26. Shet T, Desai S. Pigmented epidermal cysts. Am J Dermatopathol. 2001 Oct. 23(5):477-81. [View Abstract]
  27. Egawa K, Kitasato H, Ono T. A palmar epidermoid cyst, showing histological features suggestive of eccrine duct origin, developing after a bee-sting. Br J Dermatol. 2000 Aug. 143(2):469-70. [View Abstract]
  28. Pandhi R, Gupta S, Kumar B. Multiple epidermoid cysts on photodamaged skin sebaceous gland hyperplasia and senile. J Eur Acad Dermatol Venereol. 2001 Mar. 15(2):184-5. [View Abstract]
  29. Bechara FG, Sand M, Rotterdam S, Altmeyer P, Hoffmann K. Multiple epidermal inclusion cysts after axillary liposuction-curettage: a rare complication of a frequent procedure. Int J Dermatol. 2008 Nov. 47(11):1197-8. [View Abstract]
  30. Leppard B, Bussey HJ. Epidermoid cysts, polyposis coli and Gardner's syndrome. Br J Surg. 1975 May. 62(5):387-93. [View Abstract]
  31. Besser FS. Pachyonychia congenita with epidermal cysts and teeth at birth: 4th generation. Br J Dermatol. 1971 Jan. 84(1):95-6. [View Abstract]
  32. Takeshita T, Takeshita H, Irie K. Eruptive vellus hair cyst and epidermoid cyst in a patient with pachyonychia congenita. J Dermatol. 2000 Oct. 27(10):655-7. [View Abstract]
  33. Karacal N, Topal U, Kutlu N. Popliteal epidermoid cyst: an unusual location. Plast Reconstr Surg. 2004 Sep 1. 114(3):830-1. [View Abstract]
  34. Baran R, Broutart JC. Epidermoid cyst of the thumb presenting as pincer nail. J Am Acad Dermatol. 1988 Jul. 19(1 Pt 1):143-4. [View Abstract]
  35. Lamprou K, Plataras C, Chorti M, Christianakis E. Cutaneous Hybrid Tumor Composed of Epidermal Cyst and Cystic Pilomatricoma: Unusual Presentation in a Child. Int J Trichology. 2016 Oct-Dec. 8 (4):195-196. [View Abstract]
  36. Suliman MT. Excision of epidermoid (sebaceous) cyst: description of the operative technique. Plast Reconstr Surg. 2005 Dec. 116(7):2042-3. [View Abstract]
  37. Lieblich LM, Geronemus RG, Gibbs RC. Use of a biopsy punch for removal of epithelial cysts. J Dermatol Surg Oncol. 1982 Dec. 8(12):1059-62. [View Abstract]
  38. Mehrabi D, Leonhardt JM, Brodell RT. Removal of keratinous and pilar cysts with the punch incision technique: analysis of surgical outcomes. Dermatol Surg. 2002 Aug. 28(8):673-7. [View Abstract]
  39. Zuber TJ. Minimal excision technique for epidermoid (sebaceous) cysts. Am Fam Physician. 2002 Apr 1. 65(7):1409-12, 1417-8, 1420. [View Abstract]
  40. Yang HJ, Yang KC. A new method for facial epidermoid cyst removal with minimal incision. J Eur Acad Dermatol Venereol. 2009 May 3. [View Abstract]
  41. Barclay L. IDSA: skin and soft tissue infections guidelines updated. Medscape Medical News. Available at http://www.medscape.com/viewarticle/827399. Accessed: June 26, 2014.
  42. [Guideline] Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of america. Clin Infect Dis. 2014 Jul 15. 59(2):e10-52. [View Abstract]
  43. Silver SGHo VCY. Benign epithelial tumors. Freedberg IM, Eisen AZ, Wolff K, et al, eds. Fitzpatrick's Dermatology in General Medicine. 6th ed. New York: McGraw-Hill; 2003. 778-779.
  44. Frank E, Macias D, Hondorp B, Kerstetter J, Inman JC. Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature. Case Rep Dermatol. 2018 Jan-Apr. 10 (1):61-68. [View Abstract]
  45. Tahim A, Ali S, Cheng L. An intra-oral approach to facial skin lumps-a move towards scarless surgery. Oral Maxillofac Surg. 2018 Jun 16. [View Abstract]

Unusually large epidermoid cyst with a prominent punctum on the back of a patient. (Ruler is in centimeters.)

Multiple epidermoid cysts on the forehead of a patient with Gardner syndrome.

Cyst containing keratinous material (hematoxylin and eosin, original magnification X1.6).

Higher-magnification view of the cyst wall of the cyst in Media File 3 demonstrates a true epidermis with a granular layer and adjacent laminated keratinous material (hematoxylin and eosin, original magnification X20).

Unusually large epidermoid cyst with a prominent punctum on the back of a patient. (Ruler is in centimeters.)

Multiple epidermoid cysts on the forehead of a patient with Gardner syndrome.

Cyst containing keratinous material (hematoxylin and eosin, original magnification X1.6).

Higher-magnification view of the cyst wall of the cyst in Media File 3 demonstrates a true epidermis with a granular layer and adjacent laminated keratinous material (hematoxylin and eosin, original magnification X20).