Immunoglobulin D Deficiency

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Background

Immunoglobulin D (IgD) deficiency is a defect of humoral immunity that is characterized by abnormally low serum levels of IgD immunoglobulins. Little is known about the normal function of IgD, and few clinical signs or symptoms are associated with its absence. Individuals with low or absent levels of IgD do not appear unusually predisposed to infections.

Pathophysiology

Genetic rearrangements occur during the maturation of B lymphocytes, eventually resulting in the surface expression of both immunoglobulin M (IgM) and IgD on mature B cells. Cell signaling occurs through this surface IgD. IgD production by B cells is stimulated by interleukin (IL)–4 and IL-10.[1]

The physiologic purpose of free serum IgD is not well understood, though it may fine tune or modulate humoral immune response.[2] In mice, IgD may substitute for some functions of IgM when IgM is absent. Studies in IgM-deficient IgM-/- mice reveal that B cells with surface expression of IgM were replaced by B cells with surface expression of IgD. Immunization of IgM-/- mice revealed an IgD immune response in place of the now absent IgM response, although with a delayed increase in antibody concentration as compared to normal.[3] Recent studies have suggested that IgD-only B cells may play a significant role in immune responses to superantigens.[4] Investigations into the evolutionary origins of IgD are also ongoing.[5, 6, 7, 8]

Low serum IgD levels are not distributed in a normal gaussian fashion.[9, 10] IgD deficiency is associated with the specific human leukocyte antigens HLA-B18, F1C30, and DR3 in a Spanish Basque population[11] and HLA-B8, SC01, DR3 in white subjects in an American study.[12] A 2008 report noted that depletion of circulating IgD+ memory B cells occurs in pediatric HIV infection, despite control of viral load with highly active anti-retroviral therapy (HAART).[13]

Epidemiology

Frequency

United States

One report indicates that approximately 11% of 371 American Red Cross blood donors and 6% of 1529 study subjects had low or undetectable IgD levels (< 0.002 mg/mL). In the study group, a number of the individuals with low IgD had rheumatologic disease (eg, juvenile rheumatoid arthritis, lupus, psoriatic arthritis, vasculitis), but the frequency of low IgD within groups of patients with each disease did not differ from the normal controls using chi-square analysis.[10] In another study, using a cutoff of 2.15 IU/mL, assays of 245 healthy adults and 301 healthy children revealed that approximately 13% of each group had low levels of IgD.[9]

Mortality/Morbidity

Low or undetectable levels of IgD, in the absence of other concurrent disease or immune defects (eg, common variable immunodeficiency, complement deficiency), are not associated with morbidity or increased mortality. Specifically, patients with low or undetectable IgD levels do not demonstrate an increased incidence of infections of any type.[14]

Sex

Overall levels of serum IgD are higher in males than females,[15] but specific incidence of abnormally low IgD is approximately equal between the sexes.[9]

Age

Children younger than 3 years, both with and without an immunodeficiency, appear to have an increased prevalence of low IgD levels.[16, 17, 18] After infancy, age is not associated with increased prevalence of low IgD levels.[9]

History

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Physical

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Causes

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Laboratory Studies

Measure all classes of quantitative immunoglobulin levels (eg, immunoglobulin A [IgA], immunoglobulin G [IgG], IgM, immunoglobulin E). However, quantification of the IgG subclass is usually not necessary. Measuring these levels helps exclude a more extensive humoral immunodeficiency (eg, common variable immunodeficiency, IgA deficiency); low levels of IgD may be associated with the presence of other immune disorders.[19, 20]

Consider screening laboratory testing for complement disorders (eg, CH50), as well.[21]

Medical Care

After excluding more extensive immunodeficiency, possibly with the assistance of an allergist or clinical immunologist, patients do not need further routine care. Longitudinal follow-up examinations with periodic quantitative immunoglobulin measurements and surveillance for immune, infectious, or rheumatologic disease are advised.

Surgical Care

Surgical measures are not a component of treatment.

Consultations

If a nonspecialist discovers the IgD deficiency, refer the patient to an allergist or clinical immunologist to help exclude other more serious related conditions.

Diet

Patients require no special diet.

Activity

Activity restrictions are not necessary.

Medication Summary

Isolated IgD deficiency does not require treatment. Specifically, intravenous or subcutaneous immunoglobulin replacement therapy is not indicated. Such immunoglobulin replacement should be considered only if an associated immunodeficiency (eg, common variable immunodeficiency) is present, which is normally treated with immunoglobulin replacement. If immunoglobulin replacement therapy is indicated, see Hypogammaglobulinemia for detailed information on dosage, contraindications, drug interactions, and precautions.

Promptly treat any infections with appropriate antibiotics. Dosage, route, and duration of therapy depend on the suspected pathogen, specific drug chosen, and response to therapy. Check the monograph of a particular antibiotic for detailed information concerning contraindications, drug interactions, and precautions.

Further Outpatient Care

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Inpatient & Outpatient Medications

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Complications

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Prognosis

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Patient Education

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Author

Camellia L Hernandez, MD, Fellow in Allergy/Immunology, Walter Reed National Military Medical Center

Disclosure: Nothing to disclose.

Coauthor(s)

Evelyn M Lomasney, MD, Fellow in Allergy/Immunology, Walter Reed National Military Medical Center; Assistant Professor, Department of Medicine, Uniformed Services University of the Health Sciences

Disclosure: Nothing to disclose.

Jeannie Lee Bay, DO, Fellow in Allergy/Immunology, Walter Reed National Military Medical Center; Assistant Professor of Pediatrics, Instructor of Medicine, Department of Pediatrics, Uniformed Services University of the Health Sciences

Disclosure: Nothing to disclose.

Taylor Banks, MD, Chief, Allergy/Immunology Clinic, Walter Reed National Military Medical Center; Assistant Professor of Pediatrics, Assistant Professor of Medicine, Uniformed Services University of the Health Sciences; Associate Program Director, NCC Allergy-Immunology Fellowship Program

Disclosure: Nothing to disclose.

Specialty Editors

Francisco Talavera, PharmD, PhD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Michael R Simon, MD, MA, Clinical Professor Emeritus, Departments of Internal Medicine and Pediatrics, Wayne State University School of Medicine; Professor, Department of Internal Medicine, Oakland University William Beaumont University School of Medicine; Adjunct Staff, Division of Allergy and Immunology, Department of Internal Medicine, William Beaumont Hospital

Disclosure: Have a 5% or greater equity interest in: Secretory IgA, Inc. ; siRNAx, Inc.<br/>Received income in an amount equal to or greater than $250 from: siRNAx, Inc.

Chief Editor

Michael A Kaliner, MD, Clinical Professor of Medicine, George Washington University School of Medicine; Medical Director, Institute for Asthma and Allergy

Disclosure: Nothing to disclose.

Additional Contributors

Donald A Dibbern, Jr, MD, Consulting Staff (Allergist), Providence St Vincent Medical Center

Disclosure: Nothing to disclose.

John M Routes, MD, Professor of Pediatrics, Medicine, Microbiology and Molecular Genetics, Chief, Section of Allergy and Clinical Immunology, Department of Pediatrics, Medical College of Wisconsin

Disclosure: Nothing to disclose.

Melvin Berger, MD, PhD, Adjunct Professor of Pediatrics and Pathology, Case Western Reserve University; Senior Medical Director, Clinical Research and Development, CSL Behring, LLC

Disclosure: Received salary from CSL Behring for employment; Received ownership interest from CSL Behring for employment; Received consulting fee from America''s Health insurance plans for subject matter expert for clinical immunization safety assessment network acvtivity of cdc.

References

  1. Levan-Petit I, Lelievre E, Barra A, et al. Th2 cytokine dependence of IgD production by normal human B cells. Int Immunol. Nov. 11:1819-1828.
  2. Geisberger R, Lamers M, Achatz G. The riddle of the dual expression of IgM and IgD. Immunology. 2006 Aug. 118(4):429-37. [View Abstract]
  3. Lutz C, Ledermann B, Kosco-Vilbois MH, et al. IgD can largely substitute for loss of IgM function in B cells. Nature. 1998. 393 (6687):797-801.
  4. Seifert M, Steimle-Grauer SA, Goossens T, Hansmann ML, Brauninger A, Kuppers R. A model for the development of human IgD-only B cells: Genotypic analyses suggest their generation in superantigen driven immune responses. Mol Immunol. 2009 Feb. 46(4):630-9. [View Abstract]
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