Benign Neoplasm of the Small Intestine



Benign tumors of the small bowel are rare clinical entities that often remain asymptomatic throughout life.[1, 2, 3, 4] Despite comprising 75% of the length and 90% of the surface area of the gastrointestinal (GI) tract, the small bowel harbors relatively few primary neoplasms and fewer than 2% of GI malignancies.[5]

Benign small-bowel tumors may develop as a single lesion or as multiple lesions of several subtypes. Subtypes include hyperplastic polyps, adenomas, gut stromal tumors, lipomas, hemangiomas, and those associated with Peutz-Jeghers syndrome.[6]

These tumors are generally characterized by slow growth and delayed clinical presentation. They often remain inherently asymptomatic, only to be discovered incidentally at autopsy.

Strict medical management currently has no role in benign small bowel tumors. Surgical excision of small bowel tumors remains the recommended therapy. (See Treatment.)


Benign small-bowel tumors may be found throughout the duodenum, jejunum, and ileum (in order of increasing frequency). Tumors may be single, multiple, or widespread, that is, as part of a polyposis syndrome. Three growth patterns have been identified, as follows:

Intraluminal lesions are most often associated with the development of secondary bowel obstruction and intussusception, whereas serosal lesions are linked to small-bowel volvulus.

Several factors have been suggested to explain both the scarcity of small-bowel lesions and the infrequency of their malignant transformation.[7] First, rapid intestinal transit through the small bowel limits contact time to the small bowel mucosa. Second, greater fluidity of small-bowel chyme may dilute luminal irritants. Third, alkaline pH may play a role, as may the low bacterial colony counts of the small bowel. Finally, higher levels of benzyl peroxidase (thought to detoxify potential carcinogens) have been detected in the small bowel.

Together, with increased levels of immunoglobulin A and widespread gut lymphoid tissue, these factors may impede the growth and development of tumors and their malignant transformation.


Benign small-bowel lesions have been documented in persons of all age groups, though the mean age of presentation reportedly is between the fifth and sixth decades of life. Several series have noted a slight predominance in males compared to females. No racial or ethnic predisposition has been discovered.


Clinically, benign small-bowel lesions are characterized by a lack of identifying symptoms. A review of published reports reveals that multiple findings can occur sporadically; no hallmark presentation has been described. Possible signs and symptoms are as follows[1, 2, 3, 4] :

The interval from symptom onset to diagnosis reportedly ranges from less than 1 month to more than 1 year, with a mean duration of symptoms of 6 months. Despite their frequently unobtrusive nature, benign small-bowel tumors may manifest primarily as secondary complications of their growth. The following may be noted:

Benign small-bowel tumors may develop as a single lesion or as multiple lesions of several subtypes. The types of tumors include the following:

Hyperplastic polyps

Hyperplastic polyps are benign mucosal growths frequently observed in the duodenum and proximal ileum. Frequently discovered upon routine upper endoscopy, the polyps may be single or multiple. They are generally asymptomatic with no malignant potential and may be removed endoscopically with biopsy forceps or an Endosnare.


Three types of small-bowel adenomas have been described, as follows:

In general, they may develop as single or multiple lesions, both sessile and pedunculated. Histologically, they appear as intraluminal extensions of the mucous membrane and submucosal architecture with multiple acini supported on a central fibrovascular core. Varying degrees of differentiation are encountered across and within tumors.[8]

Complications of continued growth include obstruction, bleeding, intussusception, and, occasionally, malignant degeneration, particularly with larger villous lesions.[9] Specifically, Brunner gland adenomas develop most often along the posterior wall of the duodenum at the junction of the first and second portions. Focal, multifocal, or diffuse, they exhibit benign proliferation of the Brunner glands with scattered ductal and stromal elements.

Villous adenomas, though exceedingly rare, have most frequently been described in the duodenum.[10] Bleeding and obstruction are their most common complications; although, as with their counterparts in the colon and stomach, they may be associated with malignant degeneration. Villous adenomas larger than 4 cm are at particular risk for malignant elements.[10]

Gut stromal tumors

In several reports, gut stromal tumors (formerly known as leiomyomas and leiomyosarcomas) are the most common symptomatic small-bowel lesions. They have been found in all areas of the small bowel, including within the Meckel diverticulum. Featuring nests of spindle-shaped cells located between the muscularis propria and the muscularis mucosa, these intramural lesions may form intraluminal masses, extraluminal masses, or transmural (dumbbell-shaped) lesions.[11]

Histologic features of smooth muscle may or may not be seen with light microscopy; however, this finding has not yet been assigned any prognostic value.[12, 13] Both focal lesions and annular lesions have been described, often with features of surface ulceration and/or deeper necrosis. Such degeneration may lead to bleeding and marked hemorrhage, which are the most common complications observed with this family of tumors. Minor bleeding from surface erosion may occur because the tumors are continually buffeted and bathed by intestinal contents. Brisk arterial bleeding may result from necrosis involving tumor arterioles occurring deep within the lesion.

Other complications of gut stromal tumors include bowel obstruction, intussusception, tumor perforation, and potential malignant degeneration. In general, size is the defining characteristic for complications from gut stromal tumors. The larger the tumor, the more likely it will obstruct or twist within the bowel lumen. Similarly, larger tumors are more likely to outgrow their blood supply, necrose, bleed, and degenerate.

Differentiating between benign gut stromal tumors and malignant gut stromal tumors can be difficult. In several published reviews, benign smooth muscle tumors are generally two to three times more common than the sarcoma variants. Current diagnostic criteria for pathologic examination of malignancy include tumor cell size, the degree of cellular differentiation, and the number of mitotic figures per high-power field (hpf). More than 2 mitotic figures per 10 hpf is generally considered worrisome for malignancy.[14]


Small-bowel lipomas are benign submucosal tumors of mesenchymal origin. These tumors are often located in the ileum and may frequently develop as pedunculated or submucosal lesions. They may be sessile or ependymal and may grow undetected to a size sufficient to produce symptoms of colicky abdominal pain and intermittent bowel obstruction.[15] Intussusception has also been reported.

Histologic features include collections of mature adipose tissue and fibrous tissue strands. Evidence of surface ulceration, central necrosis, and hemorrhage may be present. Collections of adipose tissue may be found near the ileocecal valve. These deposits may clinically mimic other lesions, both radiographically and endoscopically.


Hemangiomas of the small bowel are rare vascular tumors of three types, as follows[16, 17] :

Hemangiomas may be solitary or multiple and may account for up to 10% of small-bowel lesions.[18]

GI bleeding is a frequent complication. The blood loss may be chronic (resulting in longstanding occult anemia) or profound (requiring massive transfusions and/or emergency laparotomy for control of acute hemorrhage).[19]  Additional uncommon complications include small bowel obstruction, intussusception, intramural hematoma, and perforation. With light microscopy, they appear as blood-filled sinusoidal spaces intermingled with varying amounts of connective tissue. Occasionally, the lesions contain smooth muscle cells.

Diagnosis and localization of symptomatic lesions remain a challenge. Preoperative arteriography or intraoperative maneuvers, such as transillumination of the bowel or intraoperative ultrasound, may be employed to increase localization success.

Case reports have documented the successful use of capsule endoscopy to aid in the diagnosis of these often difficult-to-detect lesions.[20, 21]

Peutz-Jeghers syndrome

Peutz-Jeghers syndrome is an autosomal dominant disorder featuring mucocutaneous pigmentation (eg, on the face, lips, and buccal mucosa) and benign GI hamartomas.[6, 22]  These polyps may be found in the small bowel in up to 90% of affected individuals. The stomach and the colon are frequently involved, and tumors outside the GI tract are also described.

The hereditary defect is associated with mutation on the LKB1 gene (19p2,3).[23]  Histologically, the lesions feature a distinctive frondlike appearance with a stromal/smooth muscle core covered by acinar glands and normal mucosa. Nuclear atypia is absent.

Secondary complications are common and are often related to the significant numbers of hamartomas present within the bowel. Colicky abdominal pain, GI bleeding, and obstruction (frequently the result of intussusception) are widely described.[24]

Malignant transformation is reported, and other non-GI cancers may be found concomitantly.

Current surveillance recommendations for the small-bowel lesions include biannual barium upper GI series and flexible endoscopy beginning at age 10 years.[25]

Physical Examination

The physical examination is usually unrevealing, except in the case of larger tumors (>6 cm), which occasionally manifest as a palpable abdominal mass. Abdominal pain may occasionally be elicited upon palpation of the lesion. Most patients exhibit no distinct physical findings upon examination.

Laboratory Studies

Results from routine laboratory testing do not reveal abnormalities in most patients with small-bowel tumors. Microcytic anemia may be observed in conjunction with vascular or ulcerated bleeding lesions. Electrolyte abnormalities are not commonly identified in patients with small-bowel tumors.

Imaging Studies


Findings from plain films of the abdomen are frequently normal. Larger lesions may demonstrate signs of complete or partial small-bowel obstruction (eg, dilated small bowel, air-fluid levels, volvulus).

Barium contrast studies (eg, upper gastrointestinal [GI] series, small-bowel enteroclysis) are the most frequently used diagnostic tools.

Images from upper GI series may demonstrate the lesion in up to 29% of cases. The radiographic appearance on upper GI series includes irregular mucosal surfaces, extraluminal, barium-filled cavities (showing central lesion necrosis), and dumbbell-shaped lesions (indicating intraluminal and extraluminal growth).

Barium enema helps identify distal ileal lesions with successful reflux of contrast through the ileocecal valve.[26]

Selective arteriography may be used to aid in the diagnosis of possible vascular lesions and potential embolization of active bleeding. Both subserosal tumors and hemangiomas may be identified by a characteristic tumor blush visualized on arteriograms. Additional clues include multiple feeding arteries, irregular draining veins, and venous pooling around the lesion.

Arteriography may assist in differentiating malignant lesions from benign lesions. Benign tumors frequently receive arterial supply from either the gastroduodenal artery or the superior mesenteric artery. Malignant lesions often demonstrate aberrant arterial inflow from renal arteries, lumbar arteries, or both. (See the image below.)

View Image

Benign neoplasm of the small intestine. Arteriogram demonstrating small bowel gut stromal tumor, indicated by round tumor blush in lower right corner ....

Computed tomography

In reports, computed tomography (CT) images of the abdomen demonstrate up to 27% of benign small-bowel tumors. Gut stromal tumors larger than 2 cm are frequently imaged successfully by using CT. Accurate size, evidence of ulceration, and lesion necrosis are often detected.


Ultrasonographic images of the abdomen may demonstrate larger tumors (>4 cm) and can help differentiate intraluminal, intramural, and extraluminal growth patterns.[27]


Upper endoscopy/intraoperative enteroscopy

Upper endoscopy has been used successfully in the detection of proximal benign small bowel lesions in 12-30% of reported cases. For more distal small-bowel lesions, intraoperative enteroscopy is an effective technique that allows simultaneous palpation and visualization of the small bowel in its entirety to increase the possibility of lesion identification.[28]

Endoscopy allows concomitant biopsy of intraluminal lesions. Polypectomy may also be performed for small lesions.

Gut stromal tumors and lipomas frequently cannot be removed via endoscopy because of their deep intramural location and the subsequent elevated risk of bowel perforation during attempted removal. In addition, some authorities caution against endoscopic lesion biopsy because of the increased risk of shedding cells, which could lead to nests of local tumor recurrence. (See the image below.)

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Benign neoplasm of the small intestine. Intraoperative view of an ependymal small bowel stromal tumor. Notice the narrow lesion stalk and high degree ....

Capsule endoscopy

The newer modality of capsule endoscopy has been successfully used to detect small-bowel lesions that have previously remained undiagnosed by other methods.[20, 29, 30, 31, 32] Both color video images and transit time values can be analyzed for regional mucosal abnormalities.

Solid benign tumors, such as leiomyomas, as well as vascular lesions (eg, angiodysplasia, varices), have been identified in patients through the use of capsule endoscopy.

Medical Care

Strict medical management currently has no role in benign small-bowel tumors. Patients with suggestive abdominal pain, particularly if associated with evidence of anemia or intermittent obstruction, should be referred for surgical evaluation and management. Asymptomatic evidence of small-bowel mass, stricture, or intermittent obstruction discovered on incidental radiographs should be referred for surgical evaluation.[33]

Surgical Care

Surgical excision of small-bowel tumors remains the recommended therapy. Exploratory laparotomy with excision of the lesion provides the safest and most direct method for lesion identification and treatment. Tumors discovered incidentally at laparotomy should be removed to prevent future symptom development and secondary complications.

Both segmental resection and enterotomy/polypectomy have been used for lesion removal. If the pathology cannot be established at the time of resection, full segmental resection with adequate margins is recommended. (See the image below.) The literature confirms an excellent prognosis for tumors resected prior to tumor perforation or onset of massive gastrointestinal (GI) hemorrhage. Laparoscopic and endoscopic approaches have been described.[34, 35]

View Image

Benign neoplasm of the small intestine. Cross section of a gross ependymal small bowel stromal tumor after removal. Mixed stromal elements and a high ....


Surgical complications for small-bowel tumor resection should be minimal and limited to the technical aspects of the operation. Intraoperative bleeding, wound infections, anastomotic leak, and failure to localize the tumor at the time of operation have all been reported.

Postoperative complications include ileus, incisional hernia, and delayed small-bowel obstruction from adhesions. Given the limited amount of bowel commonly resected for these rare tumors, short-bowel syndrome is not typically a concern.

Diet and Activity

No special dietary recommendations are applicable.

Activity is generally as tolerated for the patient. If the patient requires operative exploration for a benign small bowel tumor, the postoperative activity regimen should follow the recommendation of the operative surgeon.


Consultations with either gastroenterology or general surgery may be helpful when abdominal pain of unknown origin or suspicion of small-bowel pathology exists so that the patient may benefit from full endoscopy, capsule endoscopy, or intraoperative push enteroscopy.[36]


Shawn M Terry, MD, FACS, Clinical Assistant Professor of Surgery, Penn State University College of Medicine; Consulting Staff, Department of Trauma and Emergency General Surgery, Community Medical Center

Disclosure: Nothing to disclose.


Thomas Santora, MD, Professor and Vice-Chair for Clinical Affairs, Department of Surgery, Temple University Hospital, Temple University School of Medicine

Disclosure: Nothing to disclose.

Specialty Editors

Francisco Talavera, PharmD, PhD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Amy L Friedman, MD, Professor of Surgery, Director of Transplantation, State University of New York Upstate Medical University College of Medicine, Syracuse

Disclosure: Nothing to disclose.

Chief Editor

John Geibel, MD, DSc, MSc, MA, Vice Chair and Professor, Department of Surgery, Section of Gastrointestinal Medicine, and Department of Cellular and Molecular Physiology, Yale University School of Medicine; Director, Surgical Research, Department of Surgery, Yale-New Haven Hospital; American Gastroenterological Association Fellow

Disclosure: Received royalty from AMGEN for consulting; Received ownership interest from Ardelyx for consulting.


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Benign neoplasm of the small intestine. Arteriogram demonstrating small bowel gut stromal tumor, indicated by round tumor blush in lower right corner of the image.

Benign neoplasm of the small intestine. Intraoperative view of an ependymal small bowel stromal tumor. Notice the narrow lesion stalk and high degree of vascularity.

Benign neoplasm of the small intestine. Cross section of a gross ependymal small bowel stromal tumor after removal. Mixed stromal elements and a high degree of cellularity are apparent.

Benign neoplasm of the small intestine. Arteriogram demonstrating small bowel gut stromal tumor, indicated by round tumor blush in lower right corner of the image.

Benign neoplasm of the small intestine. Intraoperative view of an ependymal small bowel stromal tumor. Notice the narrow lesion stalk and high degree of vascularity.

Benign neoplasm of the small intestine. Cross section of a gross ependymal small bowel stromal tumor after removal. Mixed stromal elements and a high degree of cellularity are apparent.